UK scientists see promise in a new approach in which they have developed a ‘biohybrid’ neural implant, which improves the connection between the brain and paralyzed limbs, based on experiments with mice.
A team led by researchers from the University of Cambridge, UK, published a study in Science Advances detailing the new device, which combines flexible electronics and stem cells. to better integrate with the nerve and enhance the function of the extremities, the Efe agency reported on Wednesday.
Using neural implants to restore function to the extremities is challenging, and most attempts have failed because scar tissue forms around the wires over time, preventing the connection between the device and the nerve. .
In the new device, the researchers placed a muscle cell layer reprogrammed from stem cells between the electrodes and living tissue, and found that the implant integrated into the host’s body and prevented scar tissue from forming.
This is the first time that induced pluripotent stem cells have been used in this way in a living organism, the researchers noted.
The cells survived in the electrode during the 28 days that the experiment lasted, and this is “the first time that this phenomenon has been observed for such a long time,” said the University of Cambridge.
“These cells give us a tremendous degree of control.“, stressed Damiano Barone, one of the authors of the study.
We can tell them how to behave and control them throughout the experience. By placing the cells between the electronics and the living body, the living body doesn’t see the electrodes, it only sees the cells, so no scar tissue is generated,” he added.
Scientists report that by combining two advanced therapies for nerve regeneration: cell and bioelectronic therapy — In a single device, the shortcomings of both approaches can be overcome, improving functionality and sensitivity.
The “biohybrid” device was implanted into the paralyzed forearm of rats. The stem cells, transformed into muscle cells before implantation, were integrated into the nerves of the animal’s forearm.
The rats did not regain movement in the forearm, but the device was able to pick up signals from the brain that control movement. If connected to the rest of the nerve or to a prosthesis, the device can help restore movement.
Although more research and testing still needs to be done before it can be used in humans, the device is a “promising development for amputees or people who have lost function in one or more limbsthe University of Cambridge said in a statement.
In addition to its potential to restore function in people who have lost the use of one or more limbs, the researchers note that their device can also be used to control prosthetics by interacting with specific axons responsible for motor control.
This interface “could revolutionize the way we interact with technology“said Amy Rochford, also an author of the study.
By combining living human cells with bioelectronic materials, we have created a system that can communicate with the brain in a more natural and intuitive way, opening up new possibilities for prosthetics, brain-machine interfaces, and even improving cognitive ability.”
Source: Observadora
