Molecular biologists at the University of California, San Diego have discovered the mechanism behind the development of breast cancer in women with type 2 diabetes.
And the journal Nature Cell Biology indicates that the pancreas gland in type 2 diabetes does not release enough of the hormone insulin, which controls the amount of sugar cells needed, leading to high blood glucose, leading to disruption. in blood flow and work. nervous system and immune system.
The researchers found that the development of breast cancer in women with type 2 diabetes was between 20 and 27 percent higher, compared to other diseases. The development of diabetes increases almost two years after the diagnosis of cancer, and in 10 years it increases by 20%. According to data from the World Health Organization, doctors annually diagnose 2.3 million women with breast cancer, which kills 685,000 women.
By examining the molecules released by cancer cells, the researchers discovered that they produce too much miR-22 RNA. The chain of these nucleotides is not commonly found outside liver tissue and cells, where the RNA molecule controls lipid metabolism and also plays an important role in the development of hepatitis C and a type of cancer.
In studying the effect of miR-122 on the organs of rats injected with RNA molecules or cancer cells, the researchers found that large accumulations of miR-122 penetrated pancreatic cells and inhibited insulin production. molecules. This way, you get the calories needed for rapid growth and reproduction, and nearby healthy cells are deprived of nutrition.
Researchers believe that cancer cells can be suppressed by returning the body’s sugar levels to normal. And insulin implants and diabetes medications slow tumor growth and relieve the feeling of rats.
The researchers hope that, thanks to these findings, it will be possible to treat breast cancer using drugs that block the action of miR-122.
Source: .tass
Source: Arabic RT
